Warning This medicine is a strong pain drug that can put you at risk for addiction, abuse, and misuse. Misuse or abuse of Tylenol w/ Codeine (acetaminophen and codeine tablets) can lead to overdose and death. Extra care is needed because hydrocodone with acetaminophen is a high-alert medicine. High-alert medicines have been proven to be safe and effective. “Can I just stop my medication?” This question, frequently asked of primary care doctors, has a complicated answer. For starters, if you are taking a medication that is controlling an ongoing medical problem like high blood pressure, diabetes or high cholesterol, you should never stop it on your own—or your problem will return. Consumer information about the medication ACETAMINOPHEN/CODEINE - ORAL (Tylenol-Codeine No.3, Tylenol-Codeine No.4, Vopac), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug ACETAMINOPHEN/CODEINE - ORAL. Acetaminophen and Codeine are supplied in tablet form for oral administration. Acetaminophen, USP, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. How to use Acetaminophen-Codeine. See also Warning section. Read the Medication Guide provided by your pharmacist before you start taking acetaminophen/codeine and each time you get a refill. Acetaminophen (Tylenol) and codeine is a prescription pain medicine. It is an opioid pain reliever used only for pain that is severe and is not helped by other types of painkillers. Codeine is an opiate used to treat pain, as a cough medicine, and for diarrhea. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen. Evidence does not support its use for acute cough. Yes, you can use acetaminophen and ibuprofen together. That combination of drugs controls very high fever in children. You need to know that they are not the similar drugs. The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers).